CBD may help with arthritis-related symptoms, such as pain, insomnia and anxiety, but there have been no rigorous clinical studies in people with arthritis to confirm this. While no major safety issues have been found with CBD when taken in moderate doses, potential drug interactions have been identified. CBD should never be used to replace disease-modifying drugs that help prevent permanent joint damage in inflammatory types of arthritis. CBD use should be discussed with your doctor in advance, with follow-up evaluations every three months or so, as would be done for any new treatment. There are no established clinical guidelines to inform usage. Experts recommend starting with a low dose, and if relief is inadequate, increase in small increments weekly. Buy from a reputable company that has each batch tested for purity, potency and safety by an independent laboratory and provides a certificate of analysis. The Basics: What Adults Should Know About CBD What is CBD? CBD, short for cannabidiol, is an active compound found in the cannabis plant. CBD is not intoxicating but may cause some drowsiness. The CBD in most products is extracted from hemp, a variety of cannabis that has only traces (up to 0.3%) of THC, the active compound that gets people high. Does CBD work for arthritis? Animal studies have suggested that CBD has pain-relieving and anti-inflammatory properties, but these effects have not been validated in quality studies in humans. Anecdotally, some people with arthritis who have tried CBD, but not all, report noticeable pain relief, sleep improvement and/or anxiety reduction. Is CBD safe to use? Research evaluating the safety of CBD is underway. At this point very little is known. So far, no serious safety concerns have been associated with moderate doses. CBD is thought to have the potential to interact with some drugs commonly taken by people with arthritis. Talk to your doctor before trying CBD if you take any of the following: corticosteroids (such as prednisone), tofacitinib (Xeljanz), naproxen (Aleve), celecoxib (Celebrex), tramadol (Ultram), certain antidepressants, including amitriptyline (Elavil), citalopram (Celexa), fluoxetine (Prozac), mirtazapine (Remeron), paroxetine (Paxil), sertraline (Zoloft), and certain medications for fibromyalgia, including gabapentin (Neurontin) and pregabalin (Lyrica). Are CBD products legal? CBD products derived from hemp are no longer considered Schedule I drugs under the federal Controlled Substances Act, but they still remain in a legal gray zone. There are changes underway on federal and state levels that will ultimately clarify the laws and regulations related to CBD-based products and sales. Despite that, they’re widely available in nearly every state and online. People who want to use CBD should check their state laws. Taking the First Step Should I give CBD a try? Without quality clinical studies on CBD and arthritis, doctors have not been able to say who might benefit from CBD, at what dose and in which form, who likely won’t benefit and who should avoid it. Still, there is agreement on several points: CBD is not a substitute for disease-modifying treatment for inflammatory arthritis. Patients who are interested in trying CBD should first talk to the health care provider who treats their arthritis before trying CBD. Together, they can review what has worked or not worked in the past, whether there are other options to try first, how to do a trial run, what to watch for and when to return for a follow-up visit to evaluate the results. Keep a symptom and dose diary to track effects. Quality CBD products can be expensive, especially when used for prolonged periods. To avoid wasting money, be completely sure that the product is truly having a positive effect on symptoms. What type of product should I consider? CBD-based products can be taken orally, applied to the skin or inhaled. There are pros and cons for each. By mouth. CBD that is swallowed, whether in capsules, food or liquid, is absorbed through the digestive tract. Absorption is slow and dosing is tricky due to the delayed onset of effect (one to two hours), unknown effects of stomach acids, recent meals and other factors. Capsules can work for daily use after a safe, effective capsule dose has been established. Experts discourage taking CBD via edibles, like gummies and cookies, because dosing is unreliable, and they are appealing to children but do not come in childproof containers. Like any medicine, edibles should be secured out of sight and reach of children. CBD can also be absorbed directly into the bloodstream by holding liquid from a spray or tincture (a liquid dosed by a dropper) under the tongue (sublingual) for 60 to 120 seconds. The taste may not be pleasant. Effects may be felt within 15 to 45 minutes. On the skin. Topical products, like lotions and balms, are applied to the skin over a painful joint. Whether these products deliver CBD below the skin is unknown. Topical products may also include common over-the-counter ingredients such as menthol, capsaicin or camphor, making it difficult to determine if a positive effect is due to the CBD or another ingredient. Inhaled. CBD can be inhaled via a vaporizing, or vape, pen. However, inhalation of vapor oils and chemical byproducts carry unknown risks, particularly for people with inflammatory arthritis. For this reason and because the Centers for Disease Control and Prevention is investigating vaping in association with widespread hospitalizations and deaths from severe pulmonary disease, vaping is not recommended. How much CBD should I use? While there are no established clinical guidelines, the medical experts consulted by the Arthritis Foundation recommend the following for adults: When preparing to take a liquid form, be aware that the CBD extract is mixed with a carrier oil, so there are two measures to know: the amount of the liquid product to take (the dose) and the amount of CBD in each dose. Go low and slow. Start with just a few milligrams of CBD in sublingual form twice a day. If relief is inadequate after one week, increase the dose by that same amount. If needed, go up in small increments over several weeks. If you find relief, continue taking that dose twice daily to maintain a stable level of CBD in the blood. If CBD alone doesn’t work and you are in a state where medical or recreational marijuana is legal, talk to your doctor about taking CBD with a very low-dose THC product. Be aware that THC, even at low levels, may get you high, creating cognitive, motor and balance issues. Try THC-containing products at home or at night first, so you can sleep off any unwanted effects. After several weeks, if you don’t find relief with CBD alone or with a combination of CBD and very low THC, CBD may not be right for you. If you experience any unwanted side effects when using a CBD product, immediately discontinue use and inform your doctor.
Due to poor eating habits, age and gender a considerable number of people around the world are suffering from acne. This medical condition is known to decrease the confidence level of the sufferer and make them prone to inferiority complex. Not many people get benefited by using natural remedies and switch to medication which in long term causes side effects. If you are dealing with such problems you can buy cannabis online. The best thing about this herb is that it does not cause any side effects and is also beneficial for several other health problems. How CBD will help you gain your confidence back? You can buy cannabis in Canada easily as Cannabidiol is considered to have an ageing effect on the human body. This feature helps to reduce the inflammation on the facial skin which is caused due to clogging of hair follicles. With the help of online dispensaries in Alberta, one can buy cannabis and a patient can even regulate the excessive sweat and sebum production which worsens the case of acne. CBD is also known to increase the production of anandamide that is known to regulate the cell growth on a human body. Excessive cell growth also causes clogging of sweat pores which results in full blown acne. Cannabidiol is also known to target the cells which are the sole cause of acne problems. The medication doesn’t cause any harm to cells which are normal. In most of the cases, the oil is applied as a topical solution on a face, either in the form of cream or as a lotion. Some other benefits that you can cash in The oil is also used to cure depression and stress symptoms along with sexual dysfunction, drowsiness, headache etc. Cannabidiol can also be taken by patients who are suffering from diabetes and heart related ailments. You can buy weed online and enjoy several health benefits.
The U.S. National Survey of Family Growth, which studied more than 50,000 people, shows that cannabis users have sex more often than non-users. The results were consistent for both men and women and across all age groups, religions, races and ethnicity, and educational and income levels. They were also repeated across multiple years. It’s not well-understood why, however. The researchers who pointed out the relationship raised the possibility that cannabis users might just be more free-spirited. “Individuals who engage in marijuana use, or would be open about use, might be more psychologically disinhibited in general than those who are not. This also might be reflected in their sex life.” (The scientists had originally set out to find out whether cannabis users had less sex than non-users, which they at first suspected was the case, and called their findings “reassuring.”)
Delta9-Tetrahydrocannabinol (THC) Phytocannabinoid Chemical Information IUPAC Name – (6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol Chemical Formula – C21H30O2 Molecular Weight – 314.46 g/mol Properties Density – n/a Boiling Point – n/a Short-term Stability (4 weeks) Sub-Freezer -70°C – No decrease in purity observed Freezer -15°C – No decrease in purity observed Refrigerator 4°C – No decrease in purity observed Room Temp 22°C – No decrease in purity observed Hot Temp 40°C – No decrease in purity observed Long-term Stability Stable for 60 months at -10°C freezer conditions has been established through real-time stability studies. Biology Confirmed Therapeutic Uses Ulcerative Colitis/Crohn’s Disease – Although further research required, can be adjunct treatment for nausea, vomiting and anorexia from UC/CD. Potential alternative to narcotics Anti-emetic – Human trials support significant benefits for chemotherapy induced nausea and vomiting vs placebo. As well as, benefit patients refractory to ondansetron. HIV/AIDS – Improve appetite, promote weight gain, and lift mood. Dosages Ulcerative Colitis/Crohn’s Disease – 115 mg THC in cannabis cigarette Acute and chronic pain – typical dosages start at 5 mg, but can be increased depending on necessity in edible or capsule form. Usually less than 100 mg. Promising Potential Applications Neuropathic pain, acute pain, fibromyalgia References https://ibd.cochrane.org/sites/ibd.cochrane.org/files/public/uploads/silverberg-_cannabis_for_the_treatment_of_ibd.pdf https://www.cochrane.org/CD012954/IBD_cannabis-and-cannabis-oil-treatment-ulcerative-colitis https://www.cochrane.org/CD012182/SYMPT_cannabis-products-adults-chronic-neuropathic-pain https://www.cochrane.org/CD009464/GYNAECA_cannabis-based-medicine-nausea-and-vomiting-people-treated-chemotherapy-cancer https://www.cochrane.org/CD005175/HIV_medical-use-of-cannabis-in-patients-with-hivaids https://www.cochrane.org/CD011694/SYMPT_cannabis-products-people-fibromyalgia About The Author Dr. Rivera-Acevedo is an Adjunct Professor in the Department of Anesthesiology, Pharmacology & Therapeutics at the University of British Columbia in Vancouver. He is also cannabinologist and consultant for various pharma companies around the world. With a BSc from the University of Puerto Rico – Cayey and PhD in Pharmacology from the University of British Columbia, he has extensive knowledge and expertise researching cannabis and its derivatives. In 2015, he established the first laboratory for cannabinoid research in the Department of Pharmacology at UBC, which is dedicated to understanding the therapeutic uses of different cannabis strains and formulations to treat different diseases. He also teaches various undergraduate courses within the department including Introduction to Pharmacology, Statistics in Science, Drug Development, Natural Health Products, and Pharmacogenomics. As former Director of Chemistry for Cannevert Therapeutics Ltd, he lead the chemistry team conducting R&D, QA/QC, and manufacturing research to improve cannabinoid extract formulations and development of new delivery methods. He also helped organize and supervise one of the first internationally recognized clinical trials with cannabis in Puerto Rico. When not in the lab, he can be found in the dojo practicing Brazilian Jiu Jitsu, teaching mindfulness to high school students with the Vancouver Crisis Centre, co-hosting the shows Cannabis Science Podcast, Cannabis Con Ciencia Podcast, and El Bus De Las 7 on Vancouver Coop Radio 100.5 FM.